Natural history of type-specific oral infection of Human Papillomavirus (HPV) was assessed in a cohort of HIV-infected men [538 men-who-have-sex-with-men (MSM); 195 heterosexuals]. Risk factors associated with oral HPV infections were examined. The overall HPV prevalence was 16%: HPV-16 was the most prevalent type [3.7% MSM; 7.8% heterosexuals]. HPV-16 prevalence in heterosexuals was associated with CD4 nadir counts <200 cells/μL (ORadjusted =3.0, 95%CI:1.4-6.3). Overall HPV incidence was similar between groups (11%), but incidence of HPV-16 was higher in heterosexuals (ORadjusted =3.2, 95%CI:1.1-9.5). Not only MSM but also HIV-infected heterosexual men are at risk for HPV-infection. Regular and careful oral inspection is needed. This article is protected by copyright. All rights reserved.
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