Cancer Low CD4 count important risk factor for oral HPV infection in patients with HIV

Published: February 23, 2015

Michael Carter
Original Article:

A low CD4 count is the single most important risk factor for oral human papillomavirus (HPV) infection in HIV-positive patients, investigators from the United States report in the online edition of the Journal of Infectious Diseases.

The risk of oral HPV was increased four-fold for individuals with a CD4 count below 200 cells/mm3 compared to patients with CD4 counts above 500 cells/mm3. Risk factors in HIV-negative patients included a high number of sexual partners and smoking tobacco and marijuana.

HIV-positive men-who-have sex with men (MSM) and women-who-have-sex-with women (WSW) were more likely to have oral HPV than heterosexual HIV-infected patients. But any association with increased risk of oral HPV ceased to be statistically significant after taking into account CD4 count.

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