President Barack Obama has warned Uganda’s President Yoweri Museveni that enacting an anti-gay law would complicate relations with the US.
Under the proposed legislation, those convicted of homosexual acts could face life imprisonment.
The law would also make it a crime not to report gay people.
Mr Museveni last month refused to sign the bill but on Friday indicated that he would approve it shortly, after receiving scientific advice.
Government spokesman Ofwono Opondo said a team of Ugandan scientists asked by the president for a report on homosexuality had told Mr Museveni that "there is no definitive gene responsible for homosexuality".
He told the AFP news agency this meant "homosexuality is not a disease but merely an abnormal behaviour which may be learned through experiences in life".
Mr Opondo said the president was under strong domestic pressure to sign the bill.
The private member’s bill originally proposed the death penalty for some offences, such as if a minor was involved or the perpetrator was HIV-positive, but that clause has been dropped.
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